Publications

Preprints

ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum. Ciaran J. McCoy, Humbeline Paupelin-Vaucelle, Peter Gorilak, Tom Beneke, Vladimir Varga, Eva Gluenz

Trypanosome morphogenesis involves recruitment of a pleckstrin homology domain protein by an orphan kinesin to the microtubule quartet. Corinna Benz, Nora Müller, Sabine Kaltenbrunner, Hana Váchová, Marie Vancová, Julius Lukeš, Vladimír Varga, Hassan Hashimi

Intraflagellar transport trains can turn around without the ciliary tip complex. Adrian Pascal Nievergelt, Ilia Zykov, Dennis Diener, Tim-Oliver Buchholz, Markus Delling, Stefan Diez, Florian Jug, Ludĕk S̆tĕpánek**, Gaia Pigino**

Publications

2022

Binó L, Mikulenková E, Štepánek L, Bernatík O, Vysloužil D, Pejšková P, Gorilák P, Huranová M, Varga V, Čajánek L: A protocol for generation and live-cell imaging analysis of primary cilia reporter cell lines. STAR Protoc 2022 3(1): 101199.

2021

Gorilak P, Pružincová M, Vachova H, Olšinová M, Schmidt Cernohorska M, Varga V: Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites. Open Biol 2021 11(9): 210131.

Hammond M, Zoltner M, Garrigan J, Butterfield E, Varga V, Lukeš J, Field MC: The distinctive flagellar proteome of Euglena gracilis illuminates the complexities of protistan flagella adaptation. New Phytol 2021 232(3): 1323-1336.

2020

Kiesel P, Alvarez Viar G, Tsoy N, Maraspini R, Gorilak P, Varga V, Honigmann A, Pigino G: The molecular structure of mammalian primary cilia revealed by cryo-electron tomography. Nat Struct Mol Biol 2020.

Vachova H, Alquicer G, Sedinova M, Sachova J, Hradilova M, Varga V: A rapid approach for in locus overexpression of Trypanosoma brucei proteins. Mol Biochem Parasitol 2020 239: 111300.

2019

Abeywickrema M, Vachova H, Farr H, Mohr T, Wheeler RJ, Lai DH, Vaughan S, Gull K, Sunter JD, Varga V: Non-equivalence in old- and new-flagellum daughter cells of a proliferative division in Trypanosoma brucei. Mol Microbiol 2019 112(3): 1024-1040.

2017

Varga V.**, Moreira-Leite F., Portman N. and Gull K.** (2017) Protein diversity in discrete structures at the distal tip of the trypanosome flagellum. PNAS 114(32):E6546-E6555.

2016

Dean S., Moreira-Leite F., Varga V. and Gull K. (2016) Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes. PNAS 113(35):E5135-43.

Selected publications prior to joining the IMG

Sunter J., Varga V., Dean S. and Gull K. (2015) A dynamic coordination of flagellum and cytoplasmic cytoskeleton assembly specifies cell morphogenesis in trypanosomes. J. Cell Sci. Advance Online Article March 3, 2015.

Hayes P.*, Varga V.*, Olego-Fernandes S., Sunter J., Ginger M. and Gull K. (2014) Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology. J Cell Biol. 206 (3), 377-384.

Leduc C.*, Padberg-Gehle K.*, Varga V.*, Helbing D.,  Diez S. and Howard J. (2012) Molecular Crowding Creates Traffic Jams of Kinesin Motors On Microtubules. PNAS 109(16):6100-5.

Bormuth V., Varga V., Howard J. and Schaeffer E. (2009). Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science 325, 870-873.

Varga V.*, Leduc C.*, Bormuth V., Diez S. and Howard J. (2009). Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell 138(6), 1174-1183.

Varga V., Helenius J., Tanaka K., Hyman A. A., Tanaka T. U. and Howard J. (2006). Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol 8, 957-962.

* equal contribution

** co-corresponding author